[PRNewswire] Cyagen and Neurophth Enter Global Strategic Collaboration to
이 글자크기로 변경됩니다.
(예시) 가장 빠른 뉴스가 있고 다양한 정보, 쌍방향 소통이 숨쉬는 다음뉴스를 만나보세요. 다음뉴스는 국내외 주요이슈와 실시간 속보, 문화생활 및 다양한 분야의 뉴스를 입체적으로 전달하고 있습니다.
Develop AI-Designed AAV Gene Therapy Vectors for Ophthalmic Disorders
(SANTA CLARA, Calif., Nov. 8, 2022 PRNewswire=연합뉴스) Cyagen today announced a strategic collaboration with Neurophth Therapeutics, Inc. to co-develop next-generation AAV gene therapy vectors for specific types of genetic ophthalmic disorders.
Under the terms of the agreement, Cyagen will apply its proprietary artificial intelligence (AI)-powered high-throughput platform to discover novel AAV vectors with optimized tissue targeting capability, tissue specificity, and productivity. Cyagen and Neurophth will both be responsible for evaluating the functional properties of the novel AAV vectors in rodent and NHP models, and Neurophth will be responsible for conducting clinical trials and commercialization for gene therapy products developed using Cyagen's novel AAV capsids. Cyagen could receive research phase and clinical phase milestone payments, as well as sales royalties that may exceed $140 million.
Solving the Challenges of Gene Therapy Research and Development
Utilizing AI and single-cell RNA-sequencing technologies, Cyagen's high-throughput AAV vector discovery platform helps overcome the present limitations of gene therapy R&D by quickly identifying next-generation AAV capsids that have enhanced tissue targeting capability, tissue specificity, and productivity. Cyagen has produced substantial experimental data for AI model training and developed proprietary machine learning algorithms to accelerate the AAV capsid identification and optimization processes compared to traditional directed evolution methods.
Recognizing the growing potential for ophthalmic gene therapy, Cyagen's Ophthalmology Research Solution platform is fully equipped with state-of-the-art ophthalmic instruments and an experienced professional team.
"Gene therapy has demonstrated great promise and potential for treating genetic ophthalmic diseases, and the ophthalmic gene therapy market has expanded exponentially in the past few years," Lance Han, president of Cyagen, said. "Together with Neurophth, we will develop the world's best AAV ophthalmic gene therapy products and bring brightness back to patients all over the world."
"Neurophth hopes to seek like-minded partners to work together to achieve breakthroughs in ophthalmic gene therapy development, and I think Cyagen is our ideal companion on the road ahead," said Bin Li, Founder, Chairman and CEO of Neurophth.
About Cyagen
Founded in 2006, Cyagen is a global provider of genetically modified rodent models and innovative one-stop cell and gene therapy solutions for R&D, including: disease model development, AAV discovery, drug efficacy studies, and more. Cyagen currently has over 900 employees and multiple facilities with a total scale of over 40,000 square meters. The company has established extensive cooperations with scientists and institutions in more than 100 countries, leading to the publication of over 6,300 academic articles - including the three major journals of CNS (Cell, Nature, Science). From its foundation in animal model development, to implementation of AI-powered tools for data analysis and therapeutic discoveries, Cyagen provides one-stop solutions for accelerating basic research and new drug R&D with our unique offering of models, data, algorithms, and services.
About Neurophth
Neurophth is China's leading gene therapy company focusing on ophthalmic diseases. NR082 (NFS-01), Neurophth' core product, designed to treat ND4-mediated Leber's hereditary optic neuropathy (ND4-LHON), has been granted Orphan Drug Designation (ODD) by the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA), and is the first Chinese gene therapy new drug that has been granted IND approval for clinical trials by Chinese National Medical Products Administration (NMPA) and the US FDA. At present, the first patient has been dosed in the Phase III clinical trial in September 2022. The company's pipeline also includes ND1-mediated LHON (the company's second new drug with ODD granted by the US FDA), autosomal dominant optic atrophy, optic nerve protection, vascular retinopathy and other preclinical candidates.
Address:
2255 Martin Avenue, Suite E, Santa Clara, CA 95050-2709, US
Call:800-921-8930 (8-6pm PST)
Email:animal-service@cyagen.com
Source: Cyagen Biomodels LLC
[편집자 주] 본고는 자료 제공사에서 제공한 것으로, 연합뉴스는 내용에 대해 어떠한 편집도 하지 않았음을 밝혀 드립니다.
(끝)
출처 : PRNewswire 보도자료
Copyright © 연합뉴스 보도자료. 무단전재 및 재배포 금지.
- 체코 당국, EDF·웨스팅하우스 '韓원전 계약' 진정 기각(종합) | 연합뉴스
- 野 "불법 공천개입" 용산 "공천지시한 적 없다"…11월 정국 격랑 | 연합뉴스
- 북한, 美대선 앞두고 ICBM 도발…정부, 새 대북 독자제재 발표 | 연합뉴스
- 우크라 "北 4천500명 이번주 국경 도착…11월중 실전투입 예상" | 연합뉴스
- 태풍 '콩레이' 비바람 안고 한반도로…정부, 피해 최소화 점검 | 연합뉴스
- 檢, '대북송금' 이화영에 2심도 징역 15년 구형…내달 29일 선고(종합2보) | 연합뉴스
- "하늘나라서 행복해야 해"…7세 초등생 친구·주민들 추모 발길(종합) | 연합뉴스
- 유럽 심장서 2천400억 최대 수출실적…세계한인경제인대회 성료 | 연합뉴스
- 여야 대표회담 사실상 무산…野 "지금 상황에선 안된다고 봐야" | 연합뉴스
- 고려아연에 칼빼든 금감원…"공개매수 중 유증, 부정거래 소지"(종합2보) | 연합뉴스